Baked Tuscan Chicken Casserole

This Baked Tuscan Chicken Casserole is a creamy, cheesy, and flavor-packed dish that’s perfect for busy weeknights or cozy weekends. Loaded with tender chicken breast, spinach, sun-dried tomatoes, garlic, and two types of cheese, it delivers comfort and nutrition in every bite. It’s low carb, gluten-free, and keto-friendly—yet rich enough to satisfy everyone at the table!

Full Recipe: 

Ingredients

  • 1 lb (450g) boneless skinless chicken breasts (about 2 breasts, sliced horizontally)

  • 6 oz frozen chopped spinach, thawed and squeezed dry

  • 3 oz cream cheese, softened

  • ⅓ cup heavy cream

  • 4 cloves garlic, minced

  • ¼ tsp salt

  • ½ tsp onion powder

  • ¼ tsp chili powder

  • ¼ tsp black pepper

  • 1 tsp Italian seasoning

  • ⅓ cup grated parmesan cheese

  • 8 oz jar sun-dried tomatoes, drained and chopped (reserve 1 tbsp oil)

  • ¾ cup grated mozzarella cheese

  • 1 tbsp fresh chopped parsley

Directions

  1. Preheat oven to 400ºF (200ºC).

  2. Lay the chicken breasts flat in a large baking dish. Season with salt, pepper, and half of the garlic.

  3. In a mixing bowl, combine spinach, cream cheese, heavy cream, remaining garlic, salt, onion powder, chili powder, black pepper, and Italian seasoning. Mix until smooth.

  4. Stir in parmesan and half of the mozzarella.

  5. Spread the mixture evenly over the chicken. Top with chopped sun-dried tomatoes and drizzle with 1 tablespoon of reserved oil.

  6. Sprinkle with the remaining mozzarella cheese.

  7. Cover loosely with foil and bake for 20 minutes. Then uncover and bake for another 15 minutes, or until chicken is cooked through (internal temperature 165ºF / 71ºC).

  8. Garnish with fresh parsley and serve immediately. Enjoy with cauliflower rice, pasta, or roasted veggies!

Nutrients (Per Serving – Approx. for 6 servings)

  • Calories: 390 kcal

  • Protein: 32g

  • Fat: 28g

  • Carbohydrates: 6g

  • Fiber: 1g

  • Sugar: 2g

  • Sodium: 620mg

  • Calcium: 210mg

  • Cholesterol: 95mg

Why This Casserole Works for Any Lifestyle

One of the standout qualities of this Tuscan chicken casserole is how well it fits into various dietary lifestyles. It’s naturally low in carbohydrates and free from gluten, making it perfect for those on keto, paleo, or gluten-free diets. Yet, despite these health-conscious credentials, the dish doesn’t skimp on flavor or satisfaction. The balance of protein-rich chicken, creamy cheeses, and nutrient-dense spinach makes it a complete meal that delivers both comfort and nutrition. It’s also easily adaptable if you’re looking to customize it for specific dietary needs or preferences.

Layers of Creamy, Cheesy Goodness

The casserole is built on layers of flavor and texture, starting with perfectly seasoned chicken breasts. These serve as the base for a luscious topping made from cream cheese, heavy cream, and a blend of seasonings that create a savory, herbaceous profile. Parmesan cheese adds a sharp, salty bite, while mozzarella melts beautifully on top, creating a golden, bubbly crust that seals in all the goodness below. Every forkful delivers creamy, cheesy comfort with a balanced richness that keeps you coming back for more. The casserole bakes into a cohesive dish where each bite is as flavorful as the last.

The Flavor Power of Sun-Dried Tomatoes and Garlic

Sun-dried tomatoes bring an essential pop of bold, tangy sweetness to this casserole. Their concentrated flavor adds depth that contrasts beautifully with the creaminess of the cheese and the mildness of the chicken. By chopping and layering them throughout the dish, every bite is infused with their signature richness. Combined with garlic, which is used both in the seasoning and the creamy mixture, the result is a bold, aromatic flavor profile that feels both rustic and elevated. Garlic’s earthiness grounds the dish, while the sun-dried tomatoes provide that spark of brightness.

Spinach for Nutrition and Texture

Spinach not only adds a pop of color to the dish but also delivers impressive nutritional value. Rich in iron, fiber, and vitamins A and C, spinach gives this dish a healthy boost without overwhelming the flavor. Using frozen chopped spinach saves time and effort while still delivering that same depth and texture. When folded into the creamy cheese mixture, the spinach provides a satisfying heartiness and a lovely contrast to the richness of the sauce. It’s an easy way to work more greens into your meal in a way that feels indulgent, not forced.

A Make-Ahead, Meal-Prep Friendly Option

This casserole is an excellent choice for meal prepping or planning ahead. You can prepare the entire dish in advance, cover it, and refrigerate it for up to 24 hours before baking. It also freezes well, making it ideal for batch cooking. After baking, the leftovers reheat beautifully and hold their texture and flavor, making for an easy lunch or dinner option later in the week. It’s a dish that simplifies busy schedules without compromising on quality. If you’re planning meals for the week, this casserole is a reliable addition to your rotation.

Versatile Serving Suggestions

One of the best things about this casserole is how versatile it is when it comes to serving options. For those watching their carbs, it pairs wonderfully with cauliflower rice or a side of roasted vegetables like broccoli, zucchini, or asparagus. For a more traditional route, you can serve it with pasta or a fresh green salad. It’s rich enough to stand on its own, but mild enough in flavor that it complements many sides. Whether you serve it with crusty bread to mop up the sauce or keep it lean with steamed veggies, this dish fits beautifully into any meal plan.

Crowd-Pleasing Comfort Food

Whether you’re cooking for picky eaters or adventurous foodies, this Tuscan chicken casserole hits the mark. It combines familiar flavors in a comforting package that’s hard to resist. Kids love the cheesy texture, while adults appreciate the balance of herbs, garlic, and sun-dried tomatoes. It’s hearty enough to feed a crowd and pretty enough to serve at a gathering or casual dinner party. The fact that it bakes all in one dish also means less cleanup, making it as practical as it is satisfying. It’s a win-win for home cooks looking for something both delicious and doable.

Easy to Customize to Your Tastes

This recipe is highly adaptable, allowing you to tweak it based on what you have on hand or what you’re craving. If you want to add extra protein, cooked bacon, Italian sausage, or even shrimp can be folded into the cheese mixture. Want more vegetables? Mushrooms, artichoke hearts, or cherry tomatoes make wonderful additions. You can play with different cheeses—swap mozzarella for provolone, gouda, or even fontina for a new twist. The Italian seasoning can also be adjusted based on your favorite herbs, and a pinch of red pepper flakes can give it a spicy kick if desired.

Balanced Nutrition in Every Bite

This dish delivers a smart balance of macronutrients that align well with clean-eating principles. High in protein from the chicken and cheese, and moderate in fat thanks to the cream and mozzarella, it provides long-lasting energy and satiety. The low carbohydrate content makes it a smart choice for those managing blood sugar or following a ketogenic lifestyle. Plus, the spinach and garlic contribute antioxidants and anti-inflammatory properties, enhancing the overall health benefits. You can feel good knowing this comfort food also supports your well-being.

Why You’ll Love This Casserole

There’s something so comforting about scooping a creamy, bubbling casserole straight from the oven and enjoying it with people you love. This Baked Tuscan Chicken Casserole is one of those meals that delivers every time—simple ingredients, bold flavor, and a texture that’s both hearty and smooth. It’s a no-fuss, feel-good recipe that doesn’t require advanced skills or hours in the kitchen. Once you try it, it’s likely to become a go-to recipe you return to again and again, no matter the season or the occasion.

Conclusion

The Baked Tuscan Chicken Casserole is more than just another easy dinner—it’s a comforting, nutritious, and deeply satisfying dish that brings everyone to the table. Packed with protein, layered with creamy and savory flavors, and bursting with vibrant ingredients like spinach, garlic, and sun-dried tomatoes, it offers both nourishment and indulgence. Whether you’re feeding a hungry family or planning a cozy night in, this casserole has everything you need in one dish. It’s the kind of recipe that earns a permanent spot in your weekly rotation—not just because it’s easy, but because it’s that good.

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